Statistical analyses

To examine connections between dieting and stroke, we made use of Cox proportional risks habits stratified from the age (mo) and you can follow-right up period to help you estimate RRs and you will 95% CIs. Players had been split into quintiles regarding collective average intake from magnesium, potassium, and you will calcium supplements to attenuate the interior-individual type and greatest show enough time-term consumption ( 18). A blended mineral eating plan get out-of magnesium, potassium, and calcium supplements have been calculated by the assigning factors to for each quintile and you can summing this new factors. Participants in the lowest quintile (quintile step 1) out-of magnesium, potassium, otherwise calcium intake acquired step 1 section for every mineral, people within the next quintile (quintile 2) received 2 things, and so forth. Cumulative averages was calculated by taking the brand new mean of the many claimed FFQ consumption doing the start of for each and every 2-y follow-up period. The collective average consumption was used in order to assume coronary attack chance of enough time of your own last came back questionnaire before second follow-up stage.

Multivariate activities have been adjusted getting ages (mo) and calendar big date (2-y go out durations) and you will integrated intakes off full times (kcal), alcohol (g/d), smoke, Bmi, physical activity, parental reputation for early myocardial infarction, postmenopausal hormonal procedures play with, thiazide fool around with, aspirin use, multivitamin have fun with, and you will reputation for diabetes, blood pressure level, and hypercholesterolemia from the standard. To test to have a great linear pattern, i tasked for each quintile the new median value and you can modeled it changeable while the a continuous adjustable. We checked-out the potential departure of linearity that with a chances ratio sample to have research from a model with the linear identity having a product for instance the linear label along with limited cubic spline transformations ( 19). I together with held analyses one to incorporated most of the step three minerals while doing so. Magnesium and you can potassium consumption have been very correlated (r = 0.79 in the NHS I; roentgen = 0.73 from the NHS II), and correlations ranging from calcium and potassium consumption (r = 0.forty-two on NHS I; roentgen = 0.41 from the NHS II), while between calcium supplements and you will magnesium consumption (roentgen = 0.54 on the NHS I; roentgen = 0.56 about NHS II) was in fact modest. This new Q try was utilized to test on heterogeneity ranging from the fresh new NHS I and you may NHS II. RRs (±SEs) for every single quintile out-of for every cohort were pooled in the fixed-consequences models to help you calculate summary prices ( 20). Likewise, the fresh updated meta-analysis implemented basic behavior ( 20) out of evaluation having heterogeneity by using the Q test and playing with repaired outcomes model to produce summation prices whenever zero ranging from-studies heterogeneity are clear; if not a haphazard-consequences design was utilized.

To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).

Overall performance

During 29 y out of go after-right up off 1980 thanks to 2010 regarding NHS We and twenty two y away from pursue-upwards out of 1989 thanks to 2011 on NHS II, all in all, 3780 incident heart attack times were ascertained. Of them times, 3237 event strokes was in fact documented from the NHS I (along with 1664 ischemic, 544 hemorrhagic, and 1029 unspecified strokes), and https://datingranking.net/fitness-dating/ you may 543 event strokes was in fact documented regarding NHS II (in addition to 186 ischemic, 92 hemorrhagic, and you can 265 unspecified shots). Age-standard services regarding investigation participants in the midpoint during the pursue-right up inside 1994 to the NHS We and in 1995 getting the newest NHS II get inside the Table step one. Girls with highest nutrient consumption was in fact very likely to use aspirin, multivitamins, and postmenopausal hormonal procedures, so much more personally productive, less likely to feel newest smokers than just was indeed ladies that have straight down mineral intake. Data for ladies in the NHS We and you may NHS II was joint because the we didn’t observe a life threatening ranging from-study heterogeneity (Q-fact P > 0.05).